Acute Liver Failure

Best Liver Failure Treatment Hospital in Delhi

The Acute Liver Failure at the Institute for Digestive & Liver Diseases is a specialised, well-equipped unit manned by trained healthcare experts offering effective treatment to patients with Acute Liver Failure (ALF). At least half the patients of ALF can be cured by medical management without a Liver Transplant. Identifying those who will improve with medical management alone is critical in deciding the treatment options for these patients. Those who don’t improve on medical treatment need an early listing for Liver Transplant. We at BLK-Max hospital believe that prevention of infection and appropriate use of renal replacement can save many patients of ALF with or without a transplant.

Core strengths of BLK-Max'S Acute Liver Failure Unit:

Separate Acute Liver Failure ICU
Dedicated medical and paramedical staff well trained in handling ALF patients
Liver Dialysis
Isolation of ALF patients from patients having other liver diseases. In order to prevent cross infection.
State-of-the-art medical care, to manage more than half of all ALF patients without a transplant
Enables timely decision of Liver Transplant
Rapid evaluation of patients requiring transplant (within 24-48 hours)
More than 90% success rate of transplant in ALF cases

What Is Acute Liver Failure?

Acute liver failure is a rare clinical syndrome that can lead to a life-threatening condition. It is also known as fulminant hepatic failure, which develops when a healthy liver suffers from massive injuries that result in clinical signs and symptoms of liver insufficiency. It involves complications, such as excessive bleeding and increasing pressure in the brain leading to a medical emergency that demand hospitalisation.

What Are The Causes For Acute Liver Failure?

A person suffering from acute liver failure due to end-stage liver disease (ESLD) might experience some of the common causes that lead to such condition of liver failure include:

Viral hepatitis (hepatitis A, B, C and E)
Iron buildup in the body (hemochromatosis)
Inherited disorders of sugar metabolism
- Galactosemia
- Glycogen storage disease
Alpha-1 antitrypsin deficiency
Accumulation of fat in the liver (nonalcoholic fatty liver disease)
Chronic Alcohol abuse
Impair blood flow to the liver
Consumption of toxic substances such as the poisonous wild mushroom Amanita phalloides
Copper accumulated in the liver (Wilson's disease)
Diseases in the veins of the liver such as Budd-Chiari syndrome
Infection, such as
- Syphilis
- Brucellosis
Liver disease caused by your body's immune system (autoimmune hepatitis)
Medications such as:
- Acetaminophen (Tylenol)
- Antibiotics,
- Nonsteroidal anti-inflammatory drugs and
- Anticonvulsants
- Methotrexate
- Isoniazid

Are You A Candidate Of Acute Liver Failure?

A doctor might evaluate the patient’s current medical condition to know whether he/she is a candidate for Acute Liver Failure. You may suffer from Acute Liver Failure if you experience:

Yellowing of your skin and eyeballs (jaundice)
Pain in your upper right abdomen
Abdominal swelling
Cerebral Oedema (Fluid build-up in your brain)
Severe breathing problems due to respiratory failure
Bleeding (haemorrhage) from the gut (bowel)
Disorientation or confusion
Excessive Sleepiness
Nausea
Vomiting
A general sense of feeling unwell (malaise)

What Are The Various Diagnosis Tests Required To Diagnose Acute Liver Failure?

Before recommending a Liver Transplant, a doctor might prescribe a patient to undergo a few examinations. The results help the doctor to evaluate the patient’s medical condition and help them create an individualised treatment plan. The list of diagnostic tests for Acute Liver Failure includes:

Complete blood count (CBC)
Liver function tests
Prothrombin time/INR
Imaging tests:
- Fibroscan
- Magnetic resonance imaging (MRI) of the abdomen/pelvis
- Computed tomography (CT) scan of abdomen/pelvis
- Ultrasound of abdomen/pelvis
- Electrocardiogram/chest X-ray
Liver biopsy: Invasive examination of liver tissue to understand the reason behind liver failure.
Other Blood tests to examine the functioning of the liver

What Is The Treatment Procedure For Acute Liver Failure?

The cause of acute liver failure may need specific treatment. Depending upon the cause, acute liver failure can sometimes be reversed with medication and treatment. However, in most of the serious conditions liver transplant is the only cure.
Acute liver failure treatments include:

Medicines:- To reduce the effect of liver failure on your body, your doctor mighty prescribes come medicines which include:cetylcysteine: To reduce acetaminophen overdose
- Proton pump inhibitor: To reduce stomach acid Other causes of acute liver failure such as Mushroom and other poisonings can also be treated with drugs that can reverse the effects of the toxin. To control the various signs and symptoms your doctor may also prescribe medication for conditions such as:
- To relieve pressure caused by excess fluid in the brain
- Screening for infections
- Preventing severe bleeding
- Intravenous (IV) fluids to maintain blood pressure
- Blood glucose (sugar) monitoring
Liver transplant: When medication therapy fails to work and unable to reverse acute liver failure, then the only treatment for this disease is a liver transplant. It is a surgical process where a surgeon removes the patient’s damaged liver and replace it with the donor’s healthy liver.When the reversal of acute liver failure is not possible, then the only suitable treatment is a liver transplant. During the process of a liver transplant, a surgeon removes the patient’s damaged liver and replaces it with a healthy liver from a donor (a donor can be a deceased donor or a living related/unrelated donor).

Choose the Best Liver Transplant Hospital in Delhi, India

What Are The Precautions One Must Take After The Treatment Of Acute Liver Failure?

The patient must follow the following precautions after the Liver Transplant:

Avoiding drinking alcohol
Do not take medications that can harm the liver
Eating less fatty foods, including red meat, eggs and cheese
Maintain a healthy weight.
Control of metabolic risk factors like:
- High blood pressure
- Diabetes
- Cholesterol
Cutting down the intake of salt in the diet
Get vaccinated
Avoid eating wild mushrooms

Are There Any Complications Involved?

The surgery might come with mild complications, such as:

Electrolyte deficiencies
Bleeding
Blood clots
Infection at the site of incision
Complications with donated liver
- Rejection
- Failure
Seizures
Recurrence of liver disease

Anti-rejection medication side effects

After a liver transplant, your doctor might prescribe you to take anti-rejection medications for the rest of your life which can cause side effects such as:

Headaches
Diarrhoea
Diabetes
Bone thinning
High blood pressure
High cholesterol

These anti-rejection drugs work by suppressing the immune system, thus they come with increased risk for infection. Doctors even prescribe medication to fight the infections caused by these anti-rejection drugs