Centre For Bone Marrow Transplant+91-11-30403040
The Bone Marrow Transplantation team at BLK-Max Super Speciality Hospital is specialised in providing world-class treatment for blood diseases, the number of cancers, and immune disorders that were once considered incurable. Our multidisciplinary team of proficient experts offers proactive patient care with close monitoring to establish immunity, tolerance, and improve survival outcomes.
The clinical mission of the unit is to design a patient-centric, disease-specific, reduced-toxicity transplantation regimens to help the patients suffering from high-risk leukaemia or lymphoma and other life-threatening conditions that can lead to bone marrow failure, autoimmune diseases, or immune deficiency.
Our efforts to continuously improve our Medical advancement and quality-of-life outcomes are second to none. We offer reduced-intensity transplantation for older patients, children and others who cannot tolerate the harsh side effects of full-intensity treatments in autologous or allogeneic transplants.
A Reduced-Intensity Transplant is also known as a ‘mini’ transplant or non-myeloablative transplant. It is one of the recently innovated modified types of transplant that replaces the patient’s blood-forming stem cells with those of a compatible donor. Patient undergoing reduced-intensity transplant receive lower doses of chemotherapy during the conditioning process. It is suitable for:
Usually, a donor can be of two types:
There are various serious health conditions related to blood disorders that require bone marrow transplant as a cure. Such illnesses include:
A Reduced-intensity transplant is a newer type of transplant that follows the same course as conventional transplants, but with less taxing levels of drugs. The transplantation procedure includes the following steps:
Step 1: Pre-transplant Process: Patient has to perform some Pre-transplant tests and procedures before the transplant. It will help the doctor to evaluate the current medical condition of the patient. The process includes:
Step 2: Conditioning Process: The conditioning regimen for reduced-intensity uses less chemotherapy and radiation than the standard myeloablative conditioning regimen. Reduced-intensity transplants simply
Step 3: Reduce Intensity Transplant: This transplant is a modified version of allogeneic transplantation, where the harvested and processed Bone marrow/Stem cells are transplanted into the body using a central venous catheter. These cells then make their way to the bone marrow space in the body, thereby offering a patient with a tendency to reconstitute the bone marrow and help regenerate the blood and immune system.
Step 4: Engraftment: In this process, the patient is seeking comprehensive care with close monitoring to look for the sign of new stem cells take root – or “engraft” – in the bone marrow.
Step 5: Post Engraftment monitoring and continuation of immunosuppression
A patient must take some of the very important precautions before and after the transplantation process, which includes:
Before the transplant:
After the Transplantation:
Are There Any Complications Involved?
In this process, a patient receives low doses of chemotherapy or radiation therapy before a transplant, which can cause rare complications like:
Other complications due to transplant include:
Since Reduced-intensity transplant is a relatively new approach of transplantation, therefore, its outcomes are not yet been clearly defined. However, its success rate is the same as that of traditional transplants as immediate treatment related complications are reduced.
Dr. Pawan Kumar Singh
Centre For Bone Marrow Transplant
Dr. Megha Verma
Centre For Bone Marrow Transplant