A haploidentical transplant is a newer type of transplant that is a potentially curative therapy for a wide variety of malignant and non-malignant disorders related to blood and bone marrow. The transplantation procedure includes the following steps:
Step 1: Pretransplant Process: A doctor might ask a patient to undergo several Pretransplant tests and procedures, in order to ensure their general health and the clinical status of the current medical condition. The process includes:
- Beginning Medical Evaluation
- Conference for Treatment Plan
- Central Venous Catheter Evaluation and Insertion
- Bone Marrow/Stem Cells Harvest: Bone marrow from the hip bone or stem cells from the blood of the half-matched donor is harvest for the transplantation process.
Step 2: Conditioning Process: The choice of conditioning process depends upon the medical condition of the patient. In this process either chemotherapy or radiation therapy or a combination of both is given to the patient:
- In the case of malignancy to destroy any type of cancer cells
- Aids the patient’s bone marrow in elevating the growth of new stem cells
- Helps in suppressing the immune system of the patient
Step 3: Haploidentical Transplant: A promising approach is used to transplant the harvested and processed Bone marrow/Stem cells into the patient's body using a central venous catheter. These cells then travel to different parts of the bones in the body, thereby offering a patient with a tendency to develop new blood cells.
Step 4: Engraftment: In this process, the close monitoring of the patient is done to aid the positive outcome of the transplant and look for the signs of the growth of new stem cells, along with supportive care.
Step 5: Post Engraftment monitoring and continuation of immunosuppression