Centre For Bone Marrow Transplant+91-11-30403040
BLK-Max Centre for Bone Marrow Transplant is part of BLK-Max Super Speciality Hospital that aims to provide patients with non-intrusive, compassionate care while advancing the understanding, treatment, cure, and prevention of blood-related diseases.
The unit is supported by a team of proficient experts who hold years of experience in performing Haploidentical Donor Transplantation and consistently treating a wide range of blood disorders and blood cancers. Our multidisciplinary team offers round-the-clock service and high-quality treatment to meet the individual needs of each patient in the best way possible.
Studies have proved that less than 30% of the patient’s find a stem cell match among family members, this number decreases to 5% in the case of people with mixed race. For approximately 70% of patients who do not have an HLA-identical sibling donor has to undertake haploidentical stem cell transplantation treatment to cure their blood-related disorders.
The term haploidentical donor refers to a half-matched donor, whose human leukocyte antigen (HLA) tissue type matches with that of the patient’s. A patient has to undergo haploidentical stem cell transplantation when he/she has no matched donor is available. Usually, a half donor is:
A haploidentical transplant is a type of allogeneic transplant, which involves the use of healthy, blood-forming cells from a half-matched donor to replace the unhealthy ones.
There are various serious health conditions related to blood disorders that require bone marrow transplant as a cure. Such illnesses include:
A haploidentical transplant is a newer type of transplant that is a potentially curative therapy for a wide variety of malignant and non-malignant disorders related to blood and bone marrow. The transplantation procedure includes the following steps:
Step 1: Pretransplant Process: A doctor might ask a patient to undergo several Pretransplant tests and procedures, in order to ensure their general health and the clinical status of the current medical condition. The process includes:
Step 2: Conditioning Process: The choice of conditioning process depends upon the medical condition of the patient. In this process either chemotherapy or radiation therapy or a combination of both is given to the patient:
Step 3: Haploidentical Transplant: A promising approach is used to transplant the harvested and processed Bone marrow/Stem cells into the patient's body using a central venous catheter. These cells then travel to different parts of the bones in the body, thereby offering a patient with a tendency to develop new blood cells.
Step 4: Engraftment: In this process, the close monitoring of the patient is done to aid the positive outcome of the transplant and look for the signs of the growth of new stem cells, along with supportive care.
Step 5: Post Engraftment monitoring and continuation of immunosuppression
A patient must take some of the very important precautions before and after the transplantation process, which includes:
Before the transplant:
After the transplant:
Generally, a patient receives high doses of chemotherapy or radiation therapy before a transplant, which come with complications such as
Other complications due to transplant include:
Since a haploidentical transplant is a relatively new approach to transplantation, therefore, the clinical research is still advancing. However, its success rate is the same as that of convectional transplants.
Dr. Pawan Kumar Singh
Centre For Bone Marrow Transplant
Dr. Megha Verma
Centre For Bone Marrow Transplant