Associate Director
Centre For Bone Marrow Transplant
+91-11-30403040The Centre for Bone Marrow transplant at BLK-Max Super Speciality Hospital is one of the most recommended units for patients needing highly specialised treatment for blood-related disorders. A team of internationally trained haematologists, haematopathologists, transfusionists and transplant physicians provide optimum patient care using a multidisciplinary approach in order to develop a more effective treatment plan and to build upon the existing understanding of the current medical condition.
The Centre offers world-class treatment facilities using advanced technology and the latest therapies to treat most of the complex conditions requiring allogeneic transplantation, with the aim of improving the quality of life of patients and their families.
Allogeneic transplantation is a type of transplantation that requires a donor (a healthy person) to donate stem cells/Bone marrow, which is transferred to that patient’s body after high-intensity chemotherapy or radiation. The donor can be a genetically similar person like a brother or sister or an unrelated person whose bone marrow matches with the patient’s bone marrow. The process of an Allogeneic Transplant includes:
The allogeneic stem cell transplant process can be done either by using bone marrow harvesting or Peripheral blood stem cells:
Body Location- Generally, bone marrow harvesting is done from hip bones, pelvis and sternum.
Alternate names- Bone marrow transplant is also known as Stem cell transplant.
There are various serious health conditions that require bone marrow transplant as a cure. Such illnesses include:
Non-Malignant Diseases
Malignant Diseases
Allogeneic transplantation is a process that offers great chances of curing the disease related to blood and bone marrow cancers and other disorders. In order to ensure high safety and better outcomes, some preparation is made by the doctor before the surgery, which a patient must follow.
Step 1: Pre-Transplant Process: A patient has to take a series of Pre-transplant tests and procedures to ensure their general health and the status of their current medical condition. This process of evaluation may take several days.
Step 2: Conditioning Process: After the completion of the medical evaluation, a patient has to undergo the conditioning process. In this process, either chemotherapy or radiation therapy or a combination of both is given to the patient to:
Step 3: Allogeneic Stem Cell Transplant: The patient undergoes cytotoxic treatment where the harvested and processed bone marrow/Stem cells are transplanted into the patient using a central venous catheter. The liquid bone marrow/stem cells travel through the bloodstream of the patient into the different places inside the bones. The transplant offers a patient’s body a tendency to create new blood cells in a process known as engraftment.
Step 4: Engraftment: In this process, the patient is under close monitoring for the sign of the growth of new stem cells along with supportive care.
Step 5: Post Engraftment Monitoring And Continuation Of Immunosuppression
Follow up
After an allogeneic stem cell transplant, the patient will stay in the hospital or visit the hospital every day for a couple of weeks. Initially, the count of red blood cells, white blood cells and platelets will be less, so antibiotics will be prescribed to prevent infection. But gradually, within 2 to 6 weeks, the number of blood cells increases to normal levels.
A patient must take some very important precautions before and after the transplantation process, which include:
Before The Transplantation:
After The Transplantation:
Generally, a patient receives high doses of chemotherapy or radiation therapy before a transplant, which comes with complications such as:
Other complications due to transplant include:
The success rate of allogeneic bone marrow is less as compared to autologous bone marrow transplant as it requires an external donor for transplantation.
Dr. Pawan Kumar Singh
Centre For Bone Marrow Transplant
Dr. Silky Jain
Centre For Bone Marrow Transplant
Dr. Megha Verma
Centre For Bone Marrow Transplant